Skip to main content

Pharmacogenomic Dosing Adjustments

Meaning

Pharmacogenomic dosing adjustments are precise modifications to the dosage or selection of pharmaceutical agents based on an individual’s unique genetic profile, specifically focusing on genes that encode drug-metabolizing enzymes and drug targets. This clinical practice utilizes pharmacogenomic testing to identify genetic polymorphisms, such as variations in Cytochrome P450 (CYP450) enzymes, that influence drug absorption, distribution, metabolism, and excretion (ADME). These adjustments are essential for maximizing therapeutic efficacy, minimizing adverse drug reactions, and optimizing hormonal health outcomes in personalized medicine.