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Pharmacogenetic Enzyme Function

Meaning

Pharmacogenetic Enzyme Function refers to the inherited variations in the activity and efficiency of specific liver enzymes, primarily those belonging to the Cytochrome P450 (CYP450) superfamily, that are responsible for metabolizing drugs and hormones. These genetic polymorphisms dictate how quickly an individual breaks down and eliminates therapeutic compounds or endogenous steroids. Understanding this function is crucial for precision dosing, as a ‘poor metabolizer’ may accumulate a drug to toxic levels, while an ‘ultrarapid metabolizer’ may clear it too quickly for efficacy. This biological variance necessitates individualized treatment plans.