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Pharmacodynamic Timing

Meaning

The precise scheduling of drug or compound administration to align with the body’s endogenous biological rhythms, such as the circadian cycle or pulsatile hormone secretion patterns, to maximize therapeutic efficacy and minimize adverse effects. This clinical practice acknowledges that the body’s response to a substance is not static but varies significantly depending on the time of day due to rhythmic changes in receptor sensitivity and metabolic activity. It is a key principle of chronopharmacology.