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Pharmacodynamic Markers

Meaning

Pharmacodynamic Markers are measurable biochemical, physiological, or molecular indicators that demonstrate the direct biological effect of a therapeutic intervention, particularly a hormone or drug, on the body. These markers are distinct from pharmacokinetic markers, as they reflect what the drug does to the body, not what the body does to the drug. In endocrinology, examples include changes in downstream gene expression, receptor occupancy levels, or a measurable change in a hormone-responsive protein, all of which confirm that the administered treatment is engaging its intended biological target. They are essential for confirming therapeutic efficacy and optimizing dosing in a personalized manner.