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Pharmacodynamic Interactions

Meaning

Pharmacodynamic interactions occur when two or more pharmaceutical agents or hormones influence the body’s response to one another at the level of the target receptor or physiological system. These interactions can result in an additive, synergistic, or antagonistic effect, altering the magnitude or duration of the intended clinical outcome. For example, two drugs that both lower blood pressure may have an additive effect, requiring careful dose adjustment to prevent hypotension. Clinicians must meticulously evaluate a patient’s entire regimen to predict and manage these complex biological consequences.