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Pharmacodynamic Calibration

Meaning

Pharmacodynamic Calibration is the clinical practice of precisely adjusting a therapeutic intervention, such as a hormone or peptide dose, based on the observed biological and physiological effects it produces in the patient, rather than solely on circulating blood levels. This calibration focuses on the drug’s effect on target tissues, functional markers, and patient-reported outcomes, which provides a direct measure of efficacy and tolerability. It is a critical component of precision medicine, ensuring that the administered dose translates into the desired clinical response at the cellular level.