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Pharmacodynamic Alterations

Meaning

Pharmacodynamic alterations describe the changes in the biological and physiological effects of a drug on the body, particularly how the drug interacts with its target receptors and signaling pathways. These alterations can manifest as a change in drug potency, efficacy, or the duration of its action, often due to physiological changes, disease states, or co-administration with other substances. In endocrinology, pharmacodynamic changes in hormone replacement therapy might involve shifts in receptor sensitivity or post-receptor signaling efficiency. Understanding these alterations is crucial for precise therapeutic dose adjustments.