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Ph Effects on Peptides

Meaning

pH effects on peptides describe how changes in the acidity or alkalinity of the surrounding solution profoundly influence the three-dimensional structure, stability, solubility, and biological activity of peptide hormones and therapeutic compounds. Since peptides contain multiple ionizable groups, the local pH determines the charge state of key amino acid residues, which is essential for maintaining their native conformation and receptor binding affinity. Maintaining physiological pH homeostasis is critical for peptide function within the body.