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PFAS Thyroid Transport

Meaning

PFAS Thyroid Transport describes the mechanism by which per- and polyfluoroalkyl substances (PFAS), a class of persistent environmental chemicals, interfere with the crucial physiological transport of thyroid hormones or their essential precursor, iodide, into the thyroid gland or target tissues. This interference acts as a form of endocrine disruption, potentially leading to altered thyroid hormone levels, impaired peripheral tissue action, and subsequent metabolic and developmental issues. The clinical implication is a chemically induced functional hypothyroidism or subclinical thyroid dysfunction, necessitating comprehensive screening and targeted detoxification strategies.