What is the Origin of Personalized Therapeutic Dosing?

The term merges 'personalized,' indicating tailoring to the individual's unique profile, with 'therapeutic dosing,' the administered amount intended to achieve a beneficial clinical effect. Its origin lies in pharmacogenomics and the recognition that standard dosing protocols result in non-responders or over-responders. This methodology emphasizes individual biological variance.

What is the Mechanism of Personalized Therapeutic Dosing?

The mechanism involves utilizing diagnostic data, such as the Bioactive Hormone Fraction or diurnal cortisol patterns, to calculate the required exogenous input needed to restore the desired physiological set-point. Dosing adjustments are then made iteratively based on symptom resolution and subsequent biomarker re-evaluation. This continuous feedback loop ensures the administered dose precisely matches the body's dynamic requirements for endocrine support.

Personalized Therapeutic Dosing

Meaning

Personalized Therapeutic Dosing is the clinical practice of tailoring the dosage and timing of hormone replacement or supportive agents to the unique physiological requirements of an individual patient based on dynamic testing. This approach moves beyond population averages, aiming for optimal receptor saturation and physiological effect while minimizing side effects associated with supra-physiological levels. Precision in dosing is paramount for achieving true endocrine optimization. It requires continuous feedback loops between intervention and assessment.