The highly individualized process of adjusting therapeutic inputs—nutrients, hormones, or signaling agents—to align precisely with an individual’s unique molecular profile, ensuring optimal receptor interaction and homeostatic balance. Calibration moves beyond population averages, recognizing that biological setpoints are unique to each person’s genetic and epigenetic landscape. This requires fine-tuning at the cellular level.
Origin
This concept is central to precision medicine, where “calibration” implies adjusting an instrument (the body’s regulatory system) against a known standard (optimal physiological function). “Molecular” emphasizes that the adjustments are informed by deep biochemical and genetic data.
Mechanism
The mechanism involves using advanced diagnostics to quantify specific molecular targets, such as receptor density or enzyme activity levels. Therapies are then selected and dosed to directly influence these targets, achieving a desired molecular configuration that promotes cellular signaling fidelity. This process ensures that exogenous support perfectly complements the existing endogenous biochemical machinery, maximizing therapeutic effect while minimizing systemic noise.
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