Question 1

What is the Meaning of Personalized Lipid Targets?

Accepted Answer

Personalized Lipid Targets are specific, evidence-based goals for an individual's lipid and lipoprotein parameters that are tailored based on their unique clinical profile, genetic predisposition, and calculated absolute cardiovascular risk. These targets move beyond generic population-based guidelines to account for factors like existing subclinical atherosclerosis, genetic dyslipidemia, and specific metabolic comorbidities, such as insulin resistance. The goal is to establish the most aggressive yet achievable lipid goals necessary to halt or regress atherosclerotic disease progression for that specific patient.

Question 2

What is the Origin of Personalized Lipid Targets?

Accepted Answer

The concept of personalized targets is a central tenet of precision medicine, recognizing that a one-size-fits-all approach to lipid management is insufficient for optimal cardiovascular risk reduction. This approach is driven by advanced diagnostics, including genetic testing and non-invasive imaging, which provide the granular data necessary to define an individual's true pathogenic burden and vulnerability. It reflects a modern, risk-stratified approach to preventative cardiology.

Question 3

What is the Mechanism of Personalized Lipid Targets?

Accepted Answer

The mechanism involves setting targets, often for LDL Particle Number (LDL-P) or ApoB, low enough to effectively reduce the concentration gradient that drives the infiltration of atherogenic particles into the arterial wall. For very high-risk individuals, the target is set to levels known to promote plaque stabilization and regression. This personalization is achieved by integrating the individual's hormonal and metabolic status with their genetic and clinical risk, ensuring the therapeutic strategy is precisely matched to the underlying disease mechanism.

Personalized Lipid Targets

Meaning

Origin

Mechanism

ApoB Is the Only Cholesterol Metric That Counts

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