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Personalized Hormone Replacement Therapy

Meaning

Personalized Hormone Replacement Therapy (PHRT) is a clinical approach to hormone balancing that moves beyond standardized dosing by tailoring the specific type, dose, delivery method, and timing of hormone administration to the unique physiological needs of an individual patient. This customization is guided by a comprehensive analysis of the patient’s symptoms, medical history, advanced laboratory data—including serum, salivary, and urinary hormone metabolites—and often genetic polymorphisms related to hormone metabolism. PHRT aims to restore hormonal balance to optimal physiological levels, maximizing therapeutic benefits while minimizing potential risks. It represents a precision medicine model for addressing endocrine decline or deficiency.