What is the Origin of Personalized Hormone Replacement?

This term merges the concept of "Hormone Replacement," the clinical act of supplying deficient hormones, with "Personalized," emphasizing customization based on individual data. Its foundation is rooted in recognizing the vast inter-individual variability in hormone metabolism and receptor sensitivity. This signifies a departure from one-size-fits-all endocrinology.

What is the Mechanism of Personalized Hormone Replacement?

The mechanism involves using baseline laboratory values, including free hormone fractions, metabolite profiles, and symptom questionnaires, to calculate the necessary therapeutic dose and formulation. This might involve optimizing estrogen to progesterone ratios or balancing testosterone with its downstream metabolites. Continuous monitoring ensures the replacement therapy maintains eubiosis within the target tissues.

Personalized Hormone Replacement

Meaning

Personalized Hormone Replacement (PHR) is a clinical approach where exogenous hormone administration is precisely tailored to an individual’s unique biochemical profile, symptoms, and risk stratification. This strategy moves beyond standard dosing to utilize individualized ratios, delivery methods, and titration schedules based on serial diagnostics. The objective is to restore endocrine function to a physiological optimum for that specific patient, not a population average. We treat the individual endocrine signature.