What is the Origin of Personalized Hormone Kinetics?

This concept is an evolution of classical pharmacokinetics, applying the principles of drug movement and disposition to the highly variable field of bioidentical hormone therapy. The term 'personalized' emphasizes the necessity of moving away from population averages, recognizing that genetic and epigenetic factors dramatically alter hormone clearance and half-life. It is a cornerstone of precision endocrinology.

What is the Mechanism of Personalized Hormone Kinetics?

The mechanism relies on identifying an individual's unique enzymatic capacity, particularly the cytochrome P450 enzymes in the liver, which mediate hormone metabolism, and the activity of conjugation enzymes. By assessing these kinetic factors, the clinician can select the most appropriate hormone delivery route, formulation, and dosing schedule to achieve a stable, therapeutic concentration without excessive peaks or troughs. This ensures sustained receptor saturation and minimizes the risk of metabolite accumulation.

Personalized Hormone Kinetics

Meaning

Personalized Hormone Kinetics refers to the comprehensive study of how an individual’s body uniquely absorbs, distributes, metabolizes, and excretes (ADME) administered or endogenously produced hormones. This goes beyond standard pharmacokinetics by integrating genetic polymorphisms, lifestyle factors, and specific organ function to predict and manage the temporal concentration profile of hormones in the circulation and target tissues. Understanding these individual variations is essential for safe and effective hormonal optimization.

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