What is the Origin of Personalized Dosing Strategy?

This strategy is a direct evolution from generalized pharmacology into precision medicine, heavily influenced by understanding individual variations in hormone receptor expression and metabolic clearance rates. It requires advanced diagnostic feedback.

What is the Mechanism of Personalized Dosing Strategy?

The mechanism involves iteratively adjusting dosage based on serial monitoring of target endpoints, such as free hormone levels or downstream functional markers. By accounting for individual variations in hepatic enzyme activity and receptor sensitivity, the strategy ensures therapeutic targets are met precisely, thereby preventing downregulation or suppression of endogenous production due to supra-physiological dosing.

Personalized Dosing Strategy

Meaning

A Personalized Dosing Strategy is an individualized regimen for therapeutic agents, developed by correlating specific patient biomarkers with required physiological effect, moving beyond standard population averages. This strategy acknowledges inherent differences in pharmacokinetics and pharmacodynamics across individuals. We aim for the minimum effective dose delivered at the optimal time for maximal receptor interaction.