What is the Origin of Personalized Dosage Kinetics?

This term adapts the established pharmacokinetic principles of ADME and applies the modifier "personalized" to emphasize that individual biological variability supersedes generalized models. Kinetics describes the time course of drug action within the system.

What is the Mechanism of Personalized Dosage Kinetics?

Personalized dosage kinetics are determined by factors unique to the patient, such as liver enzyme polymorphisms affecting drug metabolism or variations in circulating protein binding capacity, like SHBG influencing free hormone availability. By measuring plasma concentrations at specific intervals post-administration, clinicians can model the individual's half-life and clearance rate. This model then informs the titration strategy to maintain the therapeutic window and avoid iatrogenic symptom generation.

Personalized Dosage Kinetics ∞ Area

Personalized Dosage Kinetics

Meaning

The individualized study of how a specific dose of an exogenous substance, particularly a hormone, is absorbed, distributed, metabolized, and excreted (ADME) within a single patient over time, dictating the necessary frequency and magnitude of subsequent administrations. This moves beyond population-based pharmacokinetics to account for individual variations in metabolic clearance and receptor dynamics. It is the bedrock of precision endocrinology.