Hormone replacement therapy utilizing compounds that are chemically identical in molecular structure to the hormones naturally produced by the human body, specifically tailored in type, dosage, and delivery method to match the unique physiological needs and biomarker profile of an individual patient. This clinical practice ensures optimal receptor binding and minimizes the risks associated with non-identical synthetic structures. It is the gold standard for restoring and maintaining true endocrine balance and functional state.
Origin
The concept of ‘bio-identical’ hormones arose from the clinical desire to use hormones that perfectly mimic endogenous human chemistry, distinguishing them from traditional, often synthetic, hormone replacement compounds. The addition of ‘personalized’ emphasizes the modern, data-driven approach where dosage is not standardized but is precisely titrated based on individual high-resolution lab results and clinical symptomatic correlation.
Mechanism
The mechanism involves compounding pharmacies creating custom formulations of hormones, such as estradiol, progesterone, testosterone, and DHEA, derived from plant sources and chemically modified to be structurally identical to human hormones. These are then administered via routes like transdermal creams, subcutaneous pellets, or specific oral capsules, designed to mimic the body’s natural, pulsatile release patterns and achieve optimal tissue concentrations. The personalization ensures the therapeutic effect is maximized while mitigating potential side effects.
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