Persistent Organic Pollutants (POPs) are a group of toxic chemicals that resist environmental degradation, persist for long periods in the environment, bioaccumulate in the food chain, and pose a risk to human health and the ecosystem. These lipophilic compounds, which include certain pesticides, industrial chemicals, and unintentional by-products, are often endocrine-disrupting chemicals (EDCs). Their accumulation in adipose tissue presents a chronic toxicological challenge to metabolic and hormonal homeostasis.
Origin
The term was formalized in international environmental policy, notably through the Stockholm Convention on Persistent Organic Pollutants, which aimed to eliminate or restrict the production and use of these hazardous substances globally. The recognition of their persistence and long-range transport capabilities drove the need for a specific, regulatory classification.
Mechanism
POPs exert their function through multiple toxicological mechanisms, but their relevance to hormonal health lies primarily in their endocrine-disrupting properties. They often act as agonists or antagonists to nuclear hormone receptors, such as the estrogen, androgen, or thyroid receptors, or interfere with steroidogenesis pathways. By mimicking or blocking natural hormones, POPs disrupt the delicate balance of the endocrine system, leading to developmental, reproductive, and metabolic abnormalities.
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