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Peroxisome Proliferator-Activated Receptors (PPARs)

Meaning

Peroxisome Proliferator-Activated Receptors, or PPARs, are a vital group of intracellular nuclear receptor proteins that function as highly specialized, ligand-activated transcription factors, playing a critical role in regulating the expression of genes related to systemic metabolism, cellular differentiation, and proliferation. The three primary subtypes—alpha, delta/beta, and gamma—act as key sensors for various fatty acids and their bioactive derivatives, positioning them centrally in the maintenance of lipid and glucose homeostasis. They represent crucial pharmacological targets for therapeutic agents managing metabolic syndrome.