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Peroxisome Proliferator-Activated Receptors

Meaning

Peroxisome Proliferator-Activated Receptors, or PPARs, are a group of ligand-activated nuclear receptor proteins that function as transcription factors, playing a central role in regulating gene expression related to lipid metabolism, glucose homeostasis, and inflammatory responses. These receptors, which include subtypes alpha, gamma, and delta, serve as molecular sensors for fatty acids and their derivatives, linking nutritional status directly to the control of metabolic pathways. Their activity is crucial for maintaining energy balance and influencing cellular differentiation.