Skip to main content

Peroxisome Proliferator-Activated Receptor (PPAR)

Meaning

Peroxisome Proliferator-Activated Receptor (PPAR) refers to a family of three distinct nuclear receptor isoforms—alpha (α), gamma (γ), and delta (δ)—that function as ligand-activated transcription factors. These intracellular receptors are critical metabolic sensors that regulate the expression of genes involved in lipid and glucose homeostasis, energy balance, and inflammation. They represent a significant therapeutic target in endocrinology for managing metabolic disorders such as type 2 diabetes and dyslipidemia.