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Peripubertal

Meaning

Peripubertal is a precise developmental term referring to the transitional period immediately surrounding the onset of puberty, encompassing the late childhood years and the initial stages of sexual maturation. This phase is characterized by significant, rapid activation of the hypothalamic-pituitary-gonadal (HPG) axis, leading to a surge in sex steroid production and profound physical and psychological changes. Clinically, it is a critical window for monitoring growth, metabolic programming, and endocrine development.