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Peripheral Tissue Sensitivity

Meaning

Peripheral Tissue Sensitivity refers to the responsiveness and efficiency of target cells, such as those in muscle, fat, or bone, to the circulating concentration of a specific hormone. High sensitivity ensures that a hormone can exert its full biological effect even at lower, more physiological concentrations, which is a key hallmark of youthful, efficient endocrine function. Conversely, reduced sensitivity, often clinically termed resistance, necessitates higher hormone levels to achieve the same effect and is a common feature of aging and metabolic dysfunction.