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Peripheral Clock Fidelity

Meaning

Peripheral clock fidelity refers to the accuracy and robustness of the circadian rhythmicity maintained by the internal biological clocks located in various peripheral organs and tissues, such as the liver, pancreas, and adipose tissue. High fidelity indicates that these local clocks are precisely synchronized with the central Suprachiasmatic Nucleus (SCN) master clock and are executing their gene expression cycles with the correct timing and amplitude. Diminished fidelity, often due to mistimed eating or hormonal signals, contributes significantly to metabolic dysfunction, impaired detoxification, and hormonal dysregulation across the body.