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Peripheral Aromatization

Meaning

Peripheral aromatization is the biochemical process by which the enzyme aromatase converts androgens, such as testosterone and androstenedione, into estrogens outside of the primary endocrine glands. This conversion primarily occurs in peripheral tissues, most notably adipose (fat) tissue, muscle, and skin, and represents a significant source of circulating estrogen, especially in men and postmenopausal women. The efficiency of this process is a critical factor in managing the overall estrogenic burden and maintaining a healthy testosterone-to-estrogen ratio.