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Periostin

Meaning

Periostin is a secreted extracellular matrix protein that functions as a cellular adhesion molecule, playing a significant role in tissue morphogenesis, collagen fibrillogenesis, and the structural integrity of bone, skin, and periodontal ligament. While not a classic hormone, its expression is modulated by systemic factors, including various growth factors and inflammatory cytokines, making it a relevant biomarker in conditions like asthma and certain cancers, as well as in bone remodeling which is highly sensitive to endocrine status. Its presence is often indicative of active tissue repair or a chronic inflammatory process.