What is the Origin of Perimenopause Physiology?

'Peri' is a Greek prefix meaning "around" or "near," combined with 'menopause,' derived from men (month) and pausis (cessation). 'Physiology' refers to the study of the normal function of living systems. The term precisely captures the state of being "around menopause."

What is the Mechanism of Perimenopause Physiology?

The core mechanism involves the ovaries becoming less responsive to pituitary hormones, specifically FSH and LH, leading to an irregular and insufficient production of estrogen and progesterone. The resulting hormonal oscillations destabilize the hypothalamic-pituitary-ovarian (HPO) axis, leading to characteristic symptoms like vasomotor instability and menstrual cycle irregularity. This fluctuating endocrine environment is responsible for the systemic effects observed in perimenopausal women.

Perimenopause Physiology ∞ Area

Perimenopause Physiology

Meaning

Perimenopause physiology describes the dynamic and often erratic hormonal transition phase leading up to the final menstrual period, marking the onset of menopause. This phase is characterized by significant, fluctuating changes in ovarian function, specifically unpredictable surges and eventual decline in estrogen and progesterone levels, due to diminishing ovarian follicle reserve. Understanding this complex physiology is paramount for accurately diagnosing symptoms and initiating appropriate, personalized hormonal support.