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Perimenopause Inflammatory Load

Meaning

Perimenopause Inflammatory Load refers to the cumulative level of chronic, low-grade systemic inflammation that is often exacerbated during the perimenopausal transition due to fluctuating and declining ovarian hormone levels, particularly estrogen. This increased inflammatory state is a critical driver of common perimenopausal symptoms, including hot flashes, mood changes, and increased visceral fat accumulation, and accelerates the risk for cardiometabolic disease and cognitive decline. Quantifying and mitigating this load is a key therapeutic target for managing this life stage.