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Perimenopause Exhaustion

Meaning

Perimenopause Exhaustion describes a profound, often debilitating state of chronic fatigue that is directly linked to the fluctuating and declining hormone levels, particularly estradiol and progesterone, during the transition phase leading up to menopause. This exhaustion is a complex symptom that goes beyond simple tiredness, involving disrupted sleep architecture, dysregulated HPA axis function, and metabolic shifts that deplete energy reserves. It is a clinically recognizable manifestation of the body’s struggle to adapt to endocrine instability.