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Perimenopause Endocrine Shift

Meaning

The Perimenopause Endocrine Shift describes the dynamic, often erratic, hormonal transition phase preceding the final menstrual period, characterized by profound fluctuations in ovarian steroidogenesis and pituitary feedback. This shift is primarily marked by an initial rise in Follicle-Stimulating Hormone (FSH) due to declining ovarian reserve, coupled with wildly fluctuating, often high, estradiol levels and a progressive decline in progesterone production. The resulting hormonal chaos is responsible for the classic vasomotor and psychological symptoms experienced by women. Understanding this shift is essential for clinically managing the transition to menopause.