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Perimenopausal Symptom Correlates

Meaning

Perimenopausal symptom correlates are the objective physiological and biochemical changes that exhibit a statistical or mechanistic relationship with the subjective clinical symptoms experienced by women during the transitional period leading up to menopause. These correlates include fluctuations in estradiol and progesterone, changes in anti-Müllerian hormone (AMH), and shifts in neuroendocrine markers that underpin mood and vasomotor instability. Identifying these precise correlates allows for a data-driven, personalized approach to symptom management that moves beyond anecdotal treatment.