Skip to main content

Perimenopausal Progesterone Titration

Meaning

Perimenopausal progesterone titration is the precise, individualized adjustment of progesterone dosage during the transition phase leading up to menopause, characterized by fluctuating ovarian hormone production. This clinical practice is necessary because progesterone levels often decline erratically and significantly before estrogen levels, leading to symptoms like sleep disturbance, anxiety, and heavy bleeding. Titration aims to smooth these hormonal fluctuations, providing symptomatic relief and maintaining the protective effects of progesterone on the endometrium and nervous system. Careful, data-driven adjustment is essential for navigating this complex endocrine phase.