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Perimenopausal Mood Swings

Meaning

Perimenopausal Mood Swings are episodes of emotional lability and rapid, often intense, shifts in affective state, including increased irritability, anxiety, or depressive symptoms, experienced during the perimenopausal transition. These shifts are a direct consequence of the unpredictable and significant fluctuations in ovarian hormone production, primarily estradiol and progesterone, as the reproductive axis begins to senesce. Clinically, these symptoms necessitate a thorough assessment of neuroendocrine balance and psychological well-being.