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Perimenopausal Metabolic Dysregulation

Meaning

Perimenopausal metabolic dysregulation refers to the cluster of adverse physiological changes in energy and glucose homeostasis that commonly manifest during the transitional phase leading up to menopause. This condition is characterized by a significant shift in body composition, specifically an increase in visceral fat accumulation and a decline in lean muscle mass, alongside emerging insulin resistance and dyslipidemia. This dysregulation is a direct consequence of fluctuating and eventually declining ovarian hormone levels, particularly estrogen and progesterone.