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Perimenopausal Hormonal Changes

Meaning

The complex, fluctuating shifts in reproductive hormone levels that occur during the transitional phase leading up to the final menstrual period, which is clinically defined as menopause. This period is characterized by erratic ovarian function, leading to significant variability in estrogen and progesterone concentrations, often resulting in symptoms like vasomotor instability, sleep disturbances, and menstrual irregularity. These changes reflect the declining number and responsiveness of ovarian follicles. Clinical management focuses on alleviating symptoms and mitigating long-term health risks associated with hormonal decline.