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Perimenopausal Estrogen Dominance

Meaning

Perimenopausal Estrogen Dominance is a clinical term describing a state during the transition to menopause where a woman experiences symptoms typically associated with an excess of estrogen relative to progesterone, despite overall fluctuating or declining hormone levels. This critical imbalance occurs because ovarian progesterone production begins to decline rapidly due to frequent anovulatory cycles, while estrogen levels, though erratic, can remain high or surge periodically. This relative hormonal imbalance is responsible for common perimenopausal symptoms like heavy menstrual bleeding, breast tenderness, and mood instability.