What is the Origin of Perimenopausal Brain Function?

The term combines Perimenopausal, derived from Greek peri (around) and menopause, with Brain Function, highlighting the specific neurological consequences of this endocrine transition. It emerged as a focus in women's health and neuroscience to better understand and treat the neuroendocrine symptoms of this life stage.

What is the Mechanism of Perimenopausal Brain Function?

The mechanism involves the withdrawal and erratic fluctuation of estradiol and progesterone, which significantly impacts neurotransmitter systems and neuronal plasticity in key brain regions like the hippocampus and prefrontal cortex. Estradiol, a potent neurosteroid, modulates cerebral blood flow and mitochondrial function; its loss contributes to the observed changes in thermoregulation, leading to hot flashes, and the transient cognitive fog often reported during this phase.

Perimenopausal Brain Function ∞ Area

Perimenopausal Brain Function

Meaning

The cognitive, emotional, and physiological processes of the central nervous system during the perimenopause, the transitional phase leading up to menopause, characterized by fluctuating and ultimately declining ovarian hormone levels. This period often involves transient changes in memory, mood regulation, sleep architecture, and vasomotor control due to the brain’s high density of estrogen and progesterone receptors.