What is the Origin of Performance Substrate Utilization?

This term is a concept from exercise physiology and metabolic endocrinology, focusing on the efficiency of fuel partitioning and oxidation within the mitochondria. It highlights the direct link between hormonal signaling and the body's choice of fuel for activity and rest. The term is fundamental to understanding insulin sensitivity and body composition.

What is the Mechanism of Performance Substrate Utilization?

Substrate utilization is largely controlled by the ratio and sensitivity of key metabolic hormones, including insulin, glucagon, and growth hormone. Optimized insulin sensitivity promotes efficient glucose uptake and storage, while a favorable hormonal environment supports the mobilization and oxidation of fatty acids, particularly during periods of fasting or low-intensity activity. Enhancing metabolic flexibility through hormonal balance allows the body to maintain stable energy levels and resist metabolic dysfunction.

Performance Substrate Utilization

Meaning

The metabolic efficiency with which the body selects and processes energy sources, such as glucose, fatty acids, and ketones, to fuel physical and cognitive demands. Optimal utilization implies a flexible metabolism capable of seamlessly switching between substrates, maximizing energy output while minimizing the accumulation of metabolic waste products. This is a critical factor for sustained energy and metabolic health.