The measurable, individualized physiological and biochemical limits that define the boundary between an individual’s normal functional capacity and a state of overtraining, fatigue, or pathological breakdown. In the context of hormonal health, these thresholds are often dictated by the capacity of the adrenal and hypothalamic-pituitary axes to manage allostatic load and recover from metabolic demands. Clinical assessment aims to identify and respect these limits for sustained wellness.
Origin
This term originates from sports science and human factors engineering, where quantifying the limits of human exertion and cognitive load is essential for optimization. Its application in clinical wellness emphasizes a personalized, data-driven approach to managing physiological reserve and preventing burnout.
Mechanism
These thresholds are mechanistically linked to the body’s allostatic load, where chronic stress or excessive demand leads to sustained high levels of cortisol and sympathetic nervous system activity. Exceeding a threshold results in endocrine fatigue, often manifesting as a blunted cortisol awakening response, an unfavorable testosterone/cortisol ratio, and a subsequent decline in both physical and cognitive performance.
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