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Performance Setpoint

Meaning

The Performance Setpoint is the individualized, physiologically regulated baseline level for a given biological variable, such as circulating free testosterone, resting metabolic rate, or cognitive processing speed, that corresponds to an individual’s peak functional state. Unlike the homeostatic setpoint, which aims for survival, the Performance Setpoint is the dynamic target for optimal health and vitality, typically residing in the upper quartile of the normal reference range or even slightly beyond. Clinical optimization seeks to elevate and maintain the body’s key setpoints to maximize long-term healthspan.