The clinically significant nadir or lowest point in the circulating concentration of key hormones—such as testosterone, cortisol, or thyroid hormones—that are essential for maintaining optimal physical and cognitive function and metabolic performance. These troughs can occur naturally as part of circadian rhythm but become problematic when pathologically low due to chronic stress, overtraining, or endocrine dysfunction.
Origin
This term is a clinical and performance-oriented phrasing, combining the endocrine concept of hormone concentration fluctuations with the physiological context of athletic and cognitive performance. “Troughs” specifically refers to the lowest points of the pulsatile or circadian secretory pattern.
Mechanism
Pathological hormone troughs often result from chronic disruption of the hypothalamic-pituitary-adrenal (HPA) or hypothalamic-pituitary-gonadal (HPG) axes. For example, prolonged high-intensity training or insufficient recovery can suppress GnRH release, leading to lower pulsatility of LH and subsequently reduced gonadal testosterone production. This results in a performance-limiting trough that impairs muscle repair and mood.
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