The quantitative study of the time course of key anabolic and catabolic hormones—such as testosterone, cortisol, and IGF-1—in response to physiological stressors or interventions, focusing on absorption, distribution, metabolism, and excretion (ADME). Precise kinetic understanding allows for the strategic timing of inputs to maximize the anabolic window and minimize the duration of catabolic signaling. It is the dynamic assessment of endocrine power.
Origin
This phrase combines ‘kinetics,’ the study of rates of change, with ‘performance hormones,’ those critical for maintaining lean mass, energy, and stress resilience. In clinical practice, tracking kinetics moves beyond steady-state measurements to understand how the body handles hormonal fluctuations during activity or recovery. It frames hormones as dynamic actors in physiology.
Mechanism
Kinetics are characterized by half-life, volume of distribution, and clearance rates, which are all influenced by receptor saturation and carrier protein binding. For example, optimizing the timing of a nutrient bolus relative to a testosterone peak can enhance its subsequent anabolic signaling efficiency by ensuring substrate availability during the hormone’s peak action phase. Analyzing these rates provides insight into receptor upregulation or downregulation tendencies.
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