The precise study and application of macronutrient composition and timing designed to maximize acute and sustained physiological output by supporting optimal endocrine function and substrate availability for work. This involves tailoring the ratio of carbohydrates, fats, and proteins to elicit the desired hormonal response—such as insulin release for anabolism or epinephrine for immediate energy mobilization. It treats the body’s fuel sources as chemical inputs requiring specific management for peak function.
Origin
This term draws parallels between human physiology and chemical engineering, focusing on the stoichiometry required for high-output biological systems. “Performance” mandates efficiency, while “Chemistry” underscores the molecular interactions governing energy release and storage. It reflects a modern, data-driven approach to sports nutrition and endocrinology integration.
Mechanism
Effective fuel chemistry ensures rapid replenishment of intramuscular glycogen post-exercise via timely carbohydrate delivery, which is facilitated by insulin action. Furthermore, strategic fat intake supports long-chain fatty acid oxidation for endurance, sparing glucose stores. The hormonal response to this chemistry, particularly the balance between insulin and glucagon, dictates whether substrates are utilized immediately or sequestered for later use, directly impacting recovery and subsequent performance capacity.
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