Endogenous or exogenous chemical compounds that directly or indirectly modulate neuronal activity and synaptic transmission to acutely improve specific aspects of physical or cognitive performance. These molecules include neurotransmitters, neuropeptides, and various pharmacological or nutritional agents designed to enhance alertness, memory, or motivation. The clinical goal is to achieve an optimal, sustainable neurochemical profile.
Origin
This terminology is broadly used in pharmacology and neuroscience, evolving from the study of psychoactive substances and their effects on human function. In the clinical context, it refers to the deliberate, ethical optimization of natural brain chemistry for well-being and longevity, focusing on endogenous production and essential cofactors.
Mechanism
These neurochemicals exert their effects by altering the concentration, reuptake, or receptor binding of key signaling molecules, such as increasing dopamine for motivation and reward or boosting acetylcholine for enhanced memory encoding and focus. Hormones like estrogen and progesterone also act as powerful neuroregulators, influencing the sensitivity of various neurotransmitter receptors and promoting synaptic health and stability.
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