What is the Origin of Peptidergic Signaling?

The term combines "peptide" with the suffix "-ergic," which is used in physiology to denote a substance that acts as a chemical messenger, similar to adrenergic or cholinergic. It identifies a distinct and widespread class of signaling molecules in the human body. The discovery of numerous regulatory peptides solidified this term's importance in physiology.

What is the Mechanism of Peptidergic Signaling?

Peptidergic signaling begins with the synthesis of a prohormone peptide, which is then cleaved into its active form and released into the circulation or synaptic cleft. Upon reaching the target cell, the peptide binds to its high-affinity receptor, initiating an intracellular cascade, often involving cyclic AMP or calcium ions, that rapidly alters cellular function. This mechanism allows for highly specific and potent regulation of biological processes, essential for maintaining systemic homeostasis.

Peptidergic Signaling

Meaning

Peptidergic signaling refers to the intercellular communication pathway mediated by peptides, which are short chains of amino acids that function as hormones, neurotransmitters, or growth factors. These signaling molecules bind to specific G-protein coupled receptors or receptor tyrosine kinases on target cells to initiate a vast array of physiological responses. This system is crucial in endocrinology, governing complex functions such as satiety regulation, pituitary hormone release, and pain modulation throughout the body.