The therapeutic use of small, biologically active peptide molecules—which act as signaling agents—to modulate specific endocrine axes, metabolic functions, or tissue repair processes. This represents a precision intervention strategy leveraging the body’s natural signaling language. The application targets receptors with high specificity to elicit a desired physiological effect.
Origin
This field stems from the discovery and synthesis of endogenous peptide hormones, such as insulin and growth hormone-releasing hormone (GHRH). Modern peptidergic compound application involves utilizing synthetic analogues to overcome limitations like short half-life or poor bioavailability.
Mechanism
Peptidergic compounds function by binding to specific G-protein coupled receptors (GPCRs) or other transmembrane receptors on target cells, initiating a cascade of intracellular events. For hormonal health, this often involves modulating the hypothalamic-pituitary unit or directly influencing peripheral tissue response, such as enhancing lipolysis or promoting muscle protein synthesis.
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