Peptide Therapy Neuroprotection is the clinical use of targeted short-chain amino acid sequences to actively safeguard neurons from damage, prevent cellular death, and preserve the structural integrity of the nervous system. This therapeutic strategy is employed to mitigate the effects of chronic inflammation, oxidative stress, excitotoxicity, and metabolic dysfunction that contribute to neurological decline. It represents a proactive, molecular approach to maintaining long-term brain health and functional reserve.
Origin
This term is a convergence of advanced pharmacology, neuroscience, and the study of regenerative medicine, recognizing the powerful, inherent protective capabilities of endogenous peptides. Research into peptides that naturally regulate brain repair and survival pathways, such as those related to nerve growth factor, laid the groundwork for this clinical application. The goal is to harness these natural signaling molecules to counteract age-related and disease-induced neural damage.
Mechanism
The mechanism involves peptides that exhibit potent anti-inflammatory and antioxidant properties, directly neutralizing reactive oxygen species and reducing glial cell activation. Many neuroprotective peptides also function by stabilizing mitochondrial membranes, preventing the release of pro-apoptotic factors, and enhancing the expression of anti-apoptotic genes. Furthermore, some compounds promote angiogenesis and cerebral blood flow, ensuring adequate nutrient and oxygen delivery, all of which are critical for neuronal survival and long-term function.
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