The clinical use of specific signaling peptides, often growth hormone secretagogues or myostatin inhibitors, to promote muscle protein synthesis, increase lean body mass, and enhance muscular strength and recovery. This therapeutic application is designed to optimize the anabolic environment and accelerate the physiological adaptations to resistance training. It is a targeted approach to body composition enhancement.
Origin
This therapeutic strategy emerged from sports medicine, anti-aging research, and endocrinology, focusing on the potent anabolic and regenerative effects of certain peptide hormones. The understanding of the IGF-1/mTOR pathway and its regulation by growth hormone and other factors provides the scientific basis for this intervention. It represents a molecular strategy for musculoskeletal health.
Mechanism
The mechanism primarily involves the deployment of peptides that stimulate the release of endogenous Growth Hormone (GH), which subsequently drives the hepatic and local production of Insulin-like Growth Factor 1 (IGF-1). IGF-1 then binds to its receptors on muscle cells, activating the Akt/mTOR signaling pathway, which is the master regulator of muscle protein synthesis and hypertrophy. Other peptides may directly influence muscle satellite cell activity or inhibit catabolic signaling molecules like myostatin, collectively shifting the net protein balance toward anabolism.
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