Peptide Therapy for Longevity is a specialized clinical approach utilizing exogenous, biologically active peptides to modulate key aging pathways and promote healthspan extension. The therapeutic goal is to leverage the precise signaling capabilities of peptides to enhance cellular repair, optimize endocrine function, and reduce age-related systemic decline. This strategy is focused on addressing the fundamental biological hallmarks of aging, such as cellular senescence and mitochondrial dysfunction.
Origin
This therapeutic field is a direct outgrowth of longevity science and endocrinology, recognizing that many endogenous peptides, like Growth Hormone-Releasing Peptides (GHRPs), naturally decline with age. The application of synthetic analogues aims to restore youthful signaling dynamics. It represents a targeted, molecular intervention in the aging process, moving beyond broad hormonal replacement.
Mechanism
The mechanism involves the systemic administration of peptides that specifically target cellular processes linked to aging, such as stimulating the somatotropic axis to increase IGF-1 for tissue repair, or modulating inflammatory pathways to reduce inflammaging. Other peptides may directly enhance mitochondrial biogenesis or promote autophagy, the cellular clean-up process. These targeted signaling actions work collectively to restore metabolic balance and cellular vitality.
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